What is amyloidosis in relation to kidney disease?

Amyloidosis in relation to kidney disease refers to the accumulation of a waxy protein known as amyloid in various tissues and organs, including the kidneys. This abnormal protein deposition can lead to a range of problems, as it disrupts normal tissue structure and function. In the kidneys, amyloid can particularly impact the glomeruli, which are crucial for filtering waste and excess substances from the blood. The buildup often results in nephrotic syndrome, characterized by proteinuria, which is excess protein in the urine, leading to complications such as fluid retention and high blood pressure.

Understanding the nature of amyloidosis is essential for managing patients with kidney disease, especially those with conditions like chronic kidney disease or systemic diseases that predispose them to amyloid deposition, such as multiple myeloma or chronic inflammatory disorders. Recognizing the presence of amyloidosis is a key aspect of evaluating and treating kidney dysfunction within these patient populations.