What does 'first use syndrome' in dialysis refer to?

'First use syndrome' in dialysis specifically refers to a reaction that can occur shortly after the initiation of treatment with a new dialyzer. This phenomenon is typically observed within the first 15-30 minutes of using a dialyzer that has not been previously used. The reaction can manifest as various symptoms, including fever, chills, and hypotension, due to the release of substances from the dialyzer or interactions with the patient's blood. It is important for healthcare professionals to be aware of this syndrome to monitor patients closely during their first treatment with a new dialyzer to promptly identify and manage any adverse reactions that may occur.